Wolf-Hirschhorn syndrome was first documented in 1961: a child with midline fusion defects. Subsequent cytogenetic studies revealed a chromosomal deletion of the short arm of chromosome 4. Clinical features include mental retardation, seizures, distinct facial appearance, and midline closure defects. The former Pitt-Rogers-Danks syndromes, caused by overlapping 4p deletions, now are considered as a part of Wolf-Hirschhorn syndrome.- Category ID : 76431
USA-based non-profit association of families of children with 4p-, offering phone support, newsletters, national biannual gathering and regional meetings.
Provides information on this genetic disorder including the diagnostic criteria, differential diagnosis, clinical description, management and etiology.